This report is an annual overview of activities led and implemented by the Migration Health Division of the International Organization for Migration (IOM) in 2021, in close collaboration with Member States, other United Nations agencies and partners in the international community, to respond to the COVID-19 pandemic, meet operational challenges and advance understanding of migration health, encourage socioeconomic development through migration, and work towards ensuring respect of the human dignity and well-being of migrants. The report illustrates the growing multidimensional migration health activities and partnerships of IOM in 2021, and demonstrates the Organization’s commitment to advancing the health of migrants and their families worldwide.